Are brain structural abnormalities useful as endophenotypes in schizophrenia?

  title={Are brain structural abnormalities useful as endophenotypes in schizophrenia?},
  author={Matcheri S. Keshavan and Konasale M. Prasad and Godfrey D. Pearlson},
  journal={International review of psychiatry},
  volume={19 4},
Endophenotypes, which represent intermediate phenotypes on the causal pathway from the genotype to the phenotype, can help unravel the molecular etiopathology of complex psychiatric disorders such as schizophrenia. Several candidate endophenotypic markers have been proposed in schizophrenia, including neurocognitive and neurophysiological impairments. Over the past three decades, there has been an impressive body of literature in support of brain structural alterations in schizophrenia, but few… CONTINUE READING

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