Are booster immunisations needed for lifelong hepatitis B immunity?

  title={Are booster immunisations needed for lifelong hepatitis B immunity?},
  author={European Consensus Group on Hepatitis B Immunity},
  journal={The Lancet},
Hepatitis B and the need for a booster dose.
  • E. Leuridan, P. van Damme
  • Medicine, Biology
    Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
  • 2011
There is no need for boosters in immunologically potent persons as long as a full course was adequately administered that respected the recommended timelines, as evidenced by studies conducted up to 20 years after the original immunization course.
Hepatitis B vaccine – do we need boosters?
The accumulated data from studies assessed indicate that protection is dependent on immune memory, rather than declining anti‐HBs responses and add additional weight to the European Consensus recommendations that following a complete course of vaccination, booster doses are unnecessary in immunocompetent persons.
Humoral and cellular immune responses to a hepatitis B vaccine booster 15-18 years after neonatal immunization.
A notable proportion of fully vaccinated adolescents had lost immune memory conferred by a plasma-derived HB vaccine 15-18 years later, which may raise concerns about the need for a booster vaccine for high-risk groups in the long run.
Waning immunity to plasma‐derived hepatitis B vaccine and the need for boosters 15 years after neonatal vaccination
It is suggested that one or more booster immunizations are needed in seronegative subjects by at least 15 years following neonatal immunization with plasma‐derived HB vaccine.
Hepatitis B Immunity and Response to Booster Vaccination in Children With Inflammatory Bowel Disease Treated With Infliximab
In pediatric IBD patients seen at a large, urban tertiary care facility in the United States, a significant minority have not been vaccinated against HBV and appear at risk for HBV because protective anti-HBs levels were absent and could not be elicited through booster immunization.
Durability of immunity by hepatitis B vaccine in Japanese health care workers depends on primary response titers and durations
It may be useful to differentiate HB vaccine responders based on their primary response durations to maintain protective levels of anti-HBs efficiently and a randomized, prospective, large-scale study is warranted to support these findings.
Challenge with hepatitis B vaccine in children previously vaccinated with a hepatitis B-containing combination vaccine
Vaccination with a HBV-containing multivalent vaccine during infancy induces a lasting immune memory that can be boosted, even in children with a decline in anti-HBs concentrations.
Decreased immune response to hepatitis B eight years after routine vaccination in Israel
It was found that the antibody levels declined with time, and no correlation was found between HBsAb titers and gestational age, birthweight and parental origin, although females generated higher mean antibody levels than males.
Persistence of Immunologic Memory in Long-Term Hemodialysis Patients and Healthcare Workers Given Hepatitis B Vaccine: Role of a Booster Dose on Antibody Response
It is concluded that patients undergoing HD not only have lower rates of immunization to HB than healthy adults, but also that these are frequently transient.