Are bombesin-like peptides involved in the mediation of stress response?

@article{Kent1998AreBP,
  title={Are bombesin-like peptides involved in the mediation of stress response?},
  author={Pam Kent and Hymie Anisman and Zul Merali},
  journal={Life sciences},
  year={1998},
  volume={62 2},
  pages={
          103-14
        }
}
The neurochemical mechanisms underlying the coincident activation of the hypothalamic-pituitary-adrenal (HPA) axis and the sympathetic nervous system in response to stress remain unclear. Central injection of the neuropeptide bombesin (BN) potently stimulates the release of epinephrine from the adrenal medulla, adrenocorticotropic hormone (ACTH) from the pituitary gland, and elicits behaviors typically associated with increased emotionality and arousal. The current studies assessed whether… Expand
Central Bombesin Activates the Hypothalamic-Pituitary-Adrenal Axis
TLDR
Results suggest that BN-like peptides may regulate certain hypothalamic and extrahypothalamic circuits, including the HPA axis, by affecting regional utilization of ir-CRH and ir-AVP, and/or by provoking the release of these peptides at the Me/Arc, thus increasing their availability downstream at the anterior pituitary and increasing circulating ACTH and corticosterone levels. Expand
Role of bombesin-related peptides in the mediation or integration of the stress response
TLDR
Evidence presented suggests that BN-LPs mediate their stress-relevant effects through activation of CRH and/or AVP neurons, and several hypothetical mechanisms for such peptidergic interactions are discussed. Expand
Impact of repeated stressor exposure on the release of corticotropin-releasing hormone, arginine-vasopressin and bombesin-like peptides at the anterior pituitary
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The sustained peptidergic alterations observed in the chronically stressed rats may have implications for the development of these stressor-related disorders. Expand
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Findings support the notion that BN-induced HPA axis and sympathetic activation are mediated, at least in part, via activation of CRH neurons. Expand
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  • N. Bernier
  • Biology, Medicine
  • General and comparative endocrinology
  • 2006
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While CRF and UI appear to participate in the stress-induced changes in feeding behaviour in fish, the role of other know components of the CRF system is not known and the extent to which the anorexigenic effects of CRF-related peptides are mediated through the hypothalamic feeding center, the HPI axis and cortisol, or via actions on descending autonomic pathways remains to be investigated. Expand
Aversive and Appetitive Events Evoke the Release of Corticotropin-Releasing Hormone and Bombesin-Like Peptides at the Central Nucleus of the Amygdala
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Differential impact of predator or immobilization stressors on central corticotropin-releasing hormone and bombesin-like peptides in Fast and Slow seizing rat
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