Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?

@article{Ktorza1997AreAM,
  title={Are animal models of diabetes relevant to the study of the genetics of non-insulin-dependent diabetes in humans?},
  author={Alain Ktorza and Christine Bernard and V Parent and Luc P{\'e}nicaud and P. Froguel and Mark Lathrop and Dominique Gauguier},
  journal={Diabetes & metabolism},
  year={1997},
  volume={23 Suppl 2},
  pages={38-46}
}
Although it is well-recognized that non-insulin-dependent diabetes-mellitus (NIDDM) shown a strong genetic component the search for candidate genes has been very difficult since NIDDM is a complex, heterogeneous, multifactorial syndrome resulting from both genetic susceptibility and environmental risk factors. Therefore, the use of inbred animal models is an essential component of genetic investigations in this field. As these lines are genetically homogeneous, it is possible to direct mating… CONTINUE READING

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