Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism

@article{Roth2009AreTC,
  title={Are There Common Biochemical and Molecular Mechanisms Controlling Manganism and Parkisonism},
  author={Jerome A. Roth},
  journal={NeuroMolecular Medicine},
  year={2009},
  volume={11},
  pages={281-296}
}
Over the past several decades there has been considerable progress in our basic knowledge as to the mechanisms and factors regulating Mn toxicity. The disorder known as manganism is associated with the preferential accumulation of Mn in the globus pallidus of the basal ganglia which is generally considered to be the major and initial site of injury. Because the area of the CNS comprising the basal ganglia is very complex and dependent on the precise function and balance of several… CONTINUE READING
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