Are Tacrolimus Pharmacokinetics Affected by Nephrotic Stage?

  title={Are Tacrolimus Pharmacokinetics Affected by Nephrotic Stage?},
  author={Mara Medeiros and Sa{\'u}l Valverde and Irma Del Moral and Luis Vel{\'a}squez-Jones and Ana Mar{\'i}a Hern{\'a}ndez and Gilberto Casta{\~n}eda-Hern{\'a}ndez and Herlinda Reyes and Guido Filler},
  journal={Therapeutic drug monitoring},
  volume={38 3},
BACKGROUND Although tacrolimus therapy is not the first-line therapy for childhood nephrotic syndrome, it is often used instead of cyclosporine to ameliorate the side effects. The pharmacokinetics (PK) of tacrolimus (Tac) can be influenced by many conditions, and it has a high plasma protein binding. The Tac PK during relapse and remission of childhood nephrotic syndrome has not been well described. METHODS We performed 14 PK profiles (with measurements before intake and 0.5, 1, 2, 4, and 12… CONTINUE READING
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