Are Spatial Memories Strengthened in the Human Hippocampus during Slow Wave Sleep?

@article{Peigneux2004AreSM,
  title={Are Spatial Memories Strengthened in the Human Hippocampus during Slow Wave Sleep?},
  author={Philippe Peigneux and Steven Laureys and Sonia Fuchs and Fabienne Collette and Fabien Perrin and Jean Reggers and Christophe Phillips and Christian Degueldre and Guy Del Fiore and Joel Aerts and Andr{\'e} Luxen and Pierre Maquet},
  journal={Neuron},
  year={2004},
  volume={44},
  pages={535-545}
}

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References

SHOWING 1-10 OF 132 REFERENCES
Reactivation of hippocampal ensemble memories during sleep.
TLDR
Recordings from large ensembles of hippocampal "place cells" in three rats showed that cells that fired together when the animal occupied particular locations in the environment exhibited an increased tendency to fire together during subsequent sleep, in comparison to sleep episodes preceding the behavioral tasks.
Replay of Neuronal Firing Sequences in Rat Hippocampus During Sleep Following Spatial Experience
TLDR
The correlated activity of rat hippocampal pyramidal cells during sleep reflects the activity of those cells during earlier spatial exploration and this memory for temporal order of neuronal firing could be produced by an interaction between the temporal integration properties of long-term potentiation and the phase shifting of spike activity with respect to the hippocampal theta rhythm.
Memory of Sequential Experience in the Hippocampus during Slow Wave Sleep
Learning-Dependent Increases in Sleep Spindle Density
TLDR
Results indicate that spindle activity during non-REM sleep is sensitive to previous learning experience, and spindle density was correlated to recall performance both before and after sleep.
Communication between neocortex and hippocampus during sleep in rodents
TLDR
A robust correlation of neuronal discharges between the somatosensory cortex and hippocampus on both slow and fine time scales in the mouse and rat is shown, suggesting that oscillation-mediated temporal links coordinate specific information transfer between neocortical and hippocampal cell assemblies.
Experience-dependent changes in cerebral activation during human REM sleep
TLDR
Using positron emission tomography and regional cerebral blood flow measurements, it is shown that waking experience influences regional brain activity during subsequent sleep and supports the hypothesis that memory traces are processed during REM sleep in humans.
Reactivation of Hippocampal Cell Assemblies: Effects of Behavioral State, Experience, and EEG Dynamics
TLDR
Pattern reinstatement was strongest during sharp wave–ripple oscillations, suggesting that these events may reflect system convergence onto attractor states corresponding to previous experiences, and do not necessarily reflect persistence of an active memory.
Firing rates of hippocampal neurons are preserved during subsequent sleep episodes and modified by novel awake experience
TLDR
In a familiar environment, the discharge frequency of simultaneously recorded individual CA1 pyramidal neurons and the coactivation of cell pairs remain highly correlated across sleep–wake–sleep sequences, but both measures were affected when new sets of neurons were activated in a novel environment.
Sleeping brain, learning brain. The role of sleep for memory systems
TLDR
These studies convincingly support the idea that sleep is deeply involved in memory functions in humans and animals and confirm or reject unequivocally the recently upheld hypothesis that consolidations of non-declarative and declarative memories are respectively dependent upon REM and NREM sleep processes.
...
...