Are PPAR alpha agonists a rational therapeutic strategy for preventing abnormalities of the diabetic kidney?


The uncontrolled diabetes mellitus may result in the induction of diabetic nephropathy, one of the detrimental microvascular complications of diabetes mellitus. Diabetic nephropathy is associated with glomerular hypertrophy, glomerulosclerosis, tubulointerstitial fibrosis, mesangial cell expansion, followed by albuminuria and reduction in glomerular… (More)
DOI: 10.1016/j.phrs.2012.01.004


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