Are New Neurons Formed in the Brains of Adult Mammals?

@article{Altman1962AreNN,
  title={Are New Neurons Formed in the Brains of Adult Mammals?},
  author={Joseph Altman},
  journal={Science},
  year={1962},
  volume={135},
  pages={1127 - 1128}
}
  • J. Altman
  • Published 30 March 1962
  • Biology
  • Science
Key MethodIn an autoradiographic investigation, the production of brain lesions in rats was combined with intracranial injection of thymidine-H(3). Nuclei of numerous glia cells were found labeled in brain regions associated with the traumatized areas. In addition, some neurons and neuroblasts showed labeling, suggesting the possibility of proliferation of neurons in adult rats.

Limits of neurogenesis in primates.

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Autoradiograms from postpubertal rhesus monkeys given single and multiple injections of tritium-labeled thymidine and killed 3 days to 6 years later displayed a slow turnover of glial cells but failed to reveal any radiolabeled neurons, suggesting a stable population of neurons in primates, including humans, may be important for the continuity of learning and memory over a lifetime.

Neurogenesis in the adult brain: death of a dogma

  • C. Gross
  • Biology
    Nature Reviews Neuroscience
  • 2000
TLDR
This perspective examines the origins of this dogma, its perseverance in the face of contradictory evidence, and its final collapse as a central assumption in the field of neuroscience.

Neurogenesis in the Adult Brain

  • F. Gage
  • Biology
    The Journal of Neuroscience
  • 2002
A milestone is marked in our understanding of the brain with the recent acceptance, contrary to early dogma, that the adult nervous system can generate new neurons. One could wonder how this dogma

Autoradiographic investigation of cell proliferation in the brains of rats and cats

TLDR
The results indicate that glia cells can multiply in the brains of young adult rats and adult cats and they support the possibility that new neurons may be formed in forebrain structures, both in rodents and carnivores.

Adult Human Hippocampal Neurogenesis: Controversy and Evidence.

DNA Synthesis and Cell Division in the Adult Primate Brain a

  • P. Rakic
  • Biology, Psychology
    Annals of the New York Academy of Sciences
  • 1985
Autoradiographic analysis of juvenile and adult monkeys that received single or multiple injection of the specific DNA precursor, [3H]thymidine, demonstrates slight turnover of glial cells, but

Progress: Neurogenesis in adult primate neocortex: an evaluation of the evidence

  • P. Rakic
  • Biology, Psychology
    Nature Reviews Neuroscience
  • 2002
TLDR
Here, the available evidence is reviewed, and the scientific basis of the claim that continuous genesis and turnover of neurons in the adult primate association neocortex is questioned is questioned.

Are there functional progenitor cells in the adult brain parenchyma

TLDR
Evidence suggests that neural progenitor cells may exist also outside SVZ and SGZ, in the parenchyma of neocortex and striatum, which opens new possibilities for progensitor cell manipulation in situ with consequent development of novel progenitors-based strategies for the treatment of human neurological disease.

ARE THERE FUNCTIONAL PROGENITOR CELLS IN THE ADULT BRAIN PARENCHYMA ?

TLDR
Evidence suggests that neural progenitor cells may exist also outside SVZ and SGZ, in the parenchyma of neocortex and striatum, which opens new possibilities for progensitor cell manipulation in situ with consequent development of novel progenitors-based strategies for the treatment of human neurological disease.
...

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