Are NSAIDs Useful to Treat Alzheimer's Disease or Mild Cognitive Impairment?

@article{Imbimbo2010AreNU,
  title={Are NSAIDs Useful to Treat Alzheimer's Disease or Mild Cognitive Impairment?},
  author={B. Imbimbo and V. Solfrizzi and F. Panza},
  journal={Frontiers in Aging Neuroscience},
  year={2010},
  volume={2}
}
Several epidemiological studies suggest that long-term use of non-steroidal anti-inflammatory drugs (NSAIDs) may protect subjects carrying one or more ε4 allele of the apolipoprotein E (APOE ε4) against the onset of Alzheimer's disease (AD). The biological mechanism of this protection is not completely understood and may involve the anti-inflammatory properties of NSAIDs or their ability of interfering with the β-amyloid (Aβ) cascade. Unfortunately, long-term, placebo-controlled clinical trials… Expand
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