Are Myogenin and MyoD1 Expression Specific for Rhabdomyosarcoma?: A Study of 150 Cases, With Emphasis on Spindle Cell Mimics

@article{Cessna2001AreMA,
  title={Are Myogenin and MyoD1 Expression Specific for Rhabdomyosarcoma?: A Study of 150 Cases, With Emphasis on Spindle Cell Mimics},
  author={Melissa H. Cessna and Holly Zhou and Sherrie L. Perkins and Sheryl R. Tripp and Lester J. Layfield and Clark Daines and Cheryl M. Coffin},
  journal={The American Journal of Surgical Pathology},
  year={2001},
  volume={25},
  pages={1150-1157}
}
Rhabdomyosarcoma (RMS), the most common soft tissue sarcoma of childhood, displays a variety of histologic patterns. Immunohistochemistry is used extensively to distinguish RMS from its mimics. Myogenin and MyoD1, myogenic transcriptional regulatory proteins expressed early in skeletal muscle differentiation, are considered sensitive and specific markers for RMS and are more specific than desmin and muscle-specific actin and more sensitive than myoglobin. Previous studies have focused on… 
Evaluation of Myogenin and MyoD1 as Immunohistochemical Markers of Canine Rhabdomyosarcoma
TLDR
It is demonstrated that MyoD1 and myogenin should be included with desmin as part of a diagnostic IHC panel for canine RMS, and utilization of these antibodies to improve the accuracy of canine R MS diagnosis will ultimately allow for better characterization of the biological behavior and clinical outcomes of this disease.
Myogenic Markers in the Evaluation of Embryonal Botryoid Rhabdomyosarcoma of the Female Genital Tract
  • W. Riedlinger, H. Kozakewich, S. Vargas
  • Medicine, Biology
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2005
TLDR
The findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology.
Myogenic Markers in the Evaluation of Embryonal Botryoid Rhabdomyosarcoma of the Female Genital Tract
  • W. Riedlinger, H. Kozakewich, S. Vargas
  • Medicine, Biology
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2005
TLDR
The findings indicate that, in this anatomic site, the diagnosis of rhabdomyosarcoma and in particular determination of tumor margins remain very reliant on histomorphology.
Diffuse Myogenin Expression by Immunohistochemistry is an Independent Marker of Poor Survival in Pediatric Rhabdomyosarcoma: A Tissue Microarray Study of 71 Primary Tumors Including Correlation With Molecular Phenotype
The pathologic classification of rhabdomyosarcoma (RMS) into embryonal or alveolar subtype is an important prognostic factor guiding the therapeutic protocol chosen for an individual patient.
PAX7 Expression in Rhabdomyosarcoma, Related Soft Tissue Tumors, and Small Round Blue Cell Neoplasms
TLDR
Investigation of the expression of PAX7, a transcriptional regulator of mammalian muscle progenitor cells implicated in the pathogenesis of rhabdomyosarcoma, finds it may be a useful diagnostic tool in the assessment of skeletal muscle differentiation in human tumors.
Expression of Myogenic Regulating Factors, Myogenin and MyoD, in Two Canine Botryoid Rhabdomyosarcomas
TLDR
The immunohistochemical reactivities of myogenin and MyoD in two canine bladder botryoid rhabdomyosarcomas that were different in the degree of differentiation were investigated and were closely correlated to the histologic features of myogenic neoplastic cells.
Pseudosarcomatous myofibroblastic tumor and myosarcoma of the urogenital tract.
TLDR
High-molecular-weight caldesmon and myogenin are useful for differentiating urogenital PMTs from myosarcomas in patients with atypical spindle-cell features.
Pediatric Benign Tumors With a Skeletal Muscle Component: Myogenin Expression, Diagnostic Pitfalls, and New Molecular Insights
  • Lara Berklite, J. Ozolek, R. Alaggio
  • Medicine
    Pediatric and developmental pathology : the official journal of the Society for Pediatric Pathology and the Paediatric Pathology Society
  • 2021
TLDR
Myogenin and MyoD1 may be variably expressed in benign lesions with skeletal muscle differentiation and the knowledge of the relationship between rhabdomyoma and RMS is expanded by identifying a shared molecular alteration in ZEB2.
The Role of Immunohistochemistry in Rhabdomyosarcoma Diagnosis Using Tissue Microarray Technology and a Xenograft Model
TLDR
There were no differences in IHC expression between the three RMS subtypes tested except fibrillin-2, which was negative in ARMS, but Applying new IHC markers can contribute to RMS diagnosis.
PAX7 Is a Sensitive Marker of Skeletal Muscle Differentiation in Rhabdomyosarcoma and Tumors With Rhabdomyosarcomatous Differentiation in the Female Genital Tract
TLDR
The utility of PAX7 as a complementary diagnostic marker of rhabdomyosarcomatous differentiation in gynecologic tumors is highlighted and should be used in combination with other markers of skeletal muscle differentiation, namely myogenin and/or MyoD1 expression is limited.
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TLDR
The results indicate that staining for myogenin is an extremely reliable and specific marker for rhabdomyoblastic differentiation and gives consistent and easily interpretable results in routinely fixed tissues.
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TLDR
Testing the diagnostic utility of monoclonal antibodies to myogenin and MyoD1 in routinely processed, formalin-fixed, and deparaffinized tissue concludes that they are both useful markers for the identification of RMS among other small blue round cell tumors of childhood, but antibodies to the latter may cross-react with an unknown cytoplasmic antigen in non-muscle cells and tumors.
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TLDR
The distribution of MyoD1 protein was highly restricted in normal tissues and was detected only in fetal skeletal muscle and more faintly in adult skeletal muscle, indicating that expression of this gene product in malignant tissue may be diagnostic for rhabdomyosarcoma.
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TLDR
A comparison of the expression profiles with those of normal developing human fetal limb muscle suggested that RMS resembled a relatively restricted segment of fetal muscle development, suggesting that the clinicopathological difference between these two subtypes may not be due to malignant transformation of the cells from different positions in the normal pathway of myogenesis.
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TLDR
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TLDR
The high level of sensitivity and specificity of MyoD1 expression indicates the value of this marker in the diagnosis of soft tissue sarcomas.
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TLDR
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TLDR
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TLDR
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