Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran.

@article{Bakhti2017AreHP,
  title={Are Helicobacter pylori highly cytotoxic genotypes and cardia gastric adenocarcinoma linked? Lessons from Iran.},
  author={Seyedeh Zahra Bakhti and Saeid Latifi-Navid and Sofia Zahri and Fatemeh Sadat Bakhti and Naser Hajavi and Abbas Yazdanbod},
  journal={Cancer biomarkers : section A of Disease markers},
  year={2017},
  volume={21 1},
  pages={
          235-246
        }
}
BACKGROUND Although the most extensive studies revealed the role of H. pylori VacA and CagA toxins in the development of gastric adenocarcinoma, the magnitude of this association and the correlations of vacA mosaicism and cagA status with cardia gastric adenocarcinoma (CGA) still remain controversial. OBJECTIVE We aimed to examine the linkage of H. pylori highly cytotoxic genotypes to CGA in Iranian populations as a model. METHODS A total of 601 Iranian patients were enrolled. Biopsies were… CONTINUE READING
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