Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide–alkyne click reaction in solution? A case study

@article{Hohloch2013AreCN,
  title={Are Cu(I)-mesoionic NHC carbenes associated with nitrogen additives the best Cu-carbene catalysts for the azide–alkyne click reaction in solution? A case study},
  author={S. Hohloch and B. Sarkar and L. Nauton and F. Cisnetti and A. Gautier},
  journal={Tetrahedron Letters},
  year={2013},
  volume={54},
  pages={1808-1812}
}
Copper(I)-catalyzed azide alkyne cycloaddition is now a widely used tool for the synthesis of elaborated compounds. Until now, few stable and efficient copper(I) catalysts are available despite the limitations inherent to approaches employing the in situ reduction of a CuII species to deliver the catalytic system. We report that the combination of a copper(I)-mesoionic N-heterocyclic carbene (MIC) with a phenanthroline derivative generates a highly active catalyst, functioning in aqueous… Expand
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