Are Canadian Inuit at increased genetic risk for coronary heart disease?

  title={Are Canadian Inuit at increased genetic risk for coronary heart disease?},
  author={Robert A Hegele and Terence K. Young and Philip W. Connelly},
  journal={Journal of Molecular Medicine},
 The Keewatin Inuit of the Northwest Territories of Canada have a very low age-adjusted mortality rate from coronary heart disease. We hypothesized that this apparent protection from disease has a genetic basis. We determined the prevalence of the disease-associated alleles of five candidate genes for atherosclerosis-related phenotypes. Surprisingly, four of the five alleles studied, namely AGT T235, FABP2 T54, PON R192 and APOE E4, were significantly more frequent in a sample of 175 Keewatin… CONTINUE READING


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SAS/STAT Guide for personal computers, version 6 edition

  • PW Connelly, DR MacLean, L Horlick, B O’Connor, A Petrasovits, JA Little
  • SAS Institute Inc
  • 1987
Highly Influential
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