Are Brazilian cervids at risk of prion diseases?

  title={Are Brazilian cervids at risk of prion diseases?},
  author={Caio Bruno Ribeiro Falc{\~a}o and Isabel Luiza de Melo Nunes Freire Lima and Jos{\'e} Maur{\'i}cio Barbanti Duarte and Jo{\~a}o Ricardo Mendes de Oliveira and Rodrigo Augusto Torres and Artur M. Wanderley and Jos{\'e} Eriton Gomes da Cunha and Jos{\'e} E. Garcia},
  pages={65 - 70}
ABSTRACT Prion diseases are neurodegenerative fatal disorders that affect human and non-human mammals. Chronic Wasting Disease (CWD) is a prion disease of cervids regarded as a public health problem in North America, and polymorphisms at specific codons in the PRNP gene are associated with this disease. To assess the potential CWD susceptibility of South American free-ranging deer, the presence of these polymorphisms was examined in Mazama gouazoubira, Ozotoceros bezoarticus and Blastocerus… 
Chronic wasting disease in Norway - a survey of prion protein gene variation among cervids.
Overall, PRNP genetic data indicate considerable susceptibility to CWD among Norwegian cervids and suggest that PRNP homozygosity may be a risk factor for the atypical CWD observed in moose.
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A retrospective pathology study of two Neotropical deer species (1995-2015), Brazil: Marsh deer (Blastocerus dichotomus) and brown brocket deer (Mazama gouazoubira)
Evidence that respiratory disease, mainly pneumonia, is a critical pathological process in these Neotropical deer species is provided, and it is proposed to prioritize respiratory disease in future research focused on South American deer health aspects.


Chronic wasting disease.
PrP genotypes of captive and free-ranging Rocky Mountain elk (Cervus elaphus nelsoni) with chronic wasting disease.
Homozygosity for Met at the corresponding polymorphic site in humans predisposes exposed individuals to some forms of Creutzfeldt-Jakob disease, and Rocky Mountain elk homozygous for PrP codon 1 32 Met were over-represented in both free-ranging and farm-raised CWD-affected elk when compared to unaffected control groups.
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It is reported that CWD can be transmitted to susceptible animals indirectly, from environments contaminated by excreta or decomposed carcasses, and environmental persistence of infectious prions will complicate efforts to control CWD and perhaps other animal prion diseases.
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Results suggest that sika deer in the Tokachi district are genetically homogeneous, and are not infected with CWD.
Prion protein polymorphisms in white-tailed deer influence susceptibility to chronic wasting disease.
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Detection of CWD Prions in Urine and Saliva of Deer by Transgenic Mouse Bioassay
The presence of infectious prions in the urine and saliva of deer with chronic wasting disease is reported and the detection of infectiousPrion protein in body fluids in other prion infections is portended.
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Monoclonal antibody F89/160.1.5, which reacts with prion protein in tissues from sheep, cattle, mule deer, and elk with naturally occurring transmissible spongiform encephalopathies, will be useful in diagnostic and pathogenesis studies of the transmissible Spongiform Encephalopathy in these ruminant species.
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Prion strains are TSE isolates that, after inoculation into distinct hosts, cause disease with consistent characteristics, such as incubation period, distinct patterns of PrPSc distribution and spongiosis and relative severity of the spongiform changes in the brain.
Genetics of prions.
Transgenetic studies argue that PrPSc acts as a template upon which PrPC is refolded into a nascent PrP sc molecule through a process facilitated by another protein.
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