Are Brand-Name and Generic Warfarin Interchangeable? Multiple N-of-1 Randomized, Crossover Trials

@article{Pereira2005AreBA,
  title={Are Brand-Name and Generic Warfarin Interchangeable? Multiple N-of-1 Randomized, Crossover Trials},
  author={J. Pereira and A. Holbrook and L. Dolovich and C. Goldsmith and L. Thabane and J. Douketis and M. Crowther and S. Bates and Jeffrey S. Ginsberg},
  journal={Annals of Pharmacotherapy},
  year={2005},
  volume={39},
  pages={1188 - 1193}
}
  • J. Pereira, A. Holbrook, +6 authors Jeffrey S. Ginsberg
  • Published 2005
  • Medicine
  • Annals of Pharmacotherapy
  • BACKGROUND Warfarin is a commonly used anticoagulant in North America. Several generic formulations have been approved, raising concern over the safety and efficacy of these products compared with brand-name Coumadin. OBJECTIVE To ensure that generic warfarin products can be safely interchanged with Coumadin. METHODS Multiple n-of-1 randomized, double-blind, crossover trials switched outpatients (N = 7) between a generic warfarin formulation (Apo-warfarin) and Coumadin over 30 weeks. Study… CONTINUE READING

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