Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis

@article{Snast2017AreBE,
  title={Are Biologics Efficacious in Atopic Dermatitis? A Systematic Review and Meta-Analysis},
  author={Igor Snast and Ofer Reiter and Emmilia Hodak and Rivka Friedland and Daniel Mimouni and Yael A Leshem},
  journal={American Journal of Clinical Dermatology},
  year={2017},
  volume={19},
  pages={145-165}
}
BackgroundCurrent systemic treatments for atopic dermatitis (AD) offer limited efficacy and are often restricted by safety concerns. Biologics may address the unmet need for improved AD therapeutics.ObjectiveThe aim of this study was to evaluate the efficacy and safety of biologic agents in AD.MethodsA systematic review and meta-analysis of studies evaluating AD patients treated with biologics was performed. The primary outcome was the Eczema Area and Severity Index (EASI)-75 response, while… 
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TLDR
The largest cohort of AD patients treated with ustekinumab in a real-world setting is presented, demonstrating the IL-12/23 pathway is not an attractive target in AD.
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TLDR
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A meta-analysis suggests that dupilumab ranks first for effectiveness when compared with other biological treatments, and the certainty of the body of evidence from the NMA for these primary outcomes is assessed using six domains of CiNEMA grading.
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TLDR
Clinical response continued to improve past 16 weeks in this real-world population of patients with AD and dupilumab provides an effective and safe treatment option for patients with atopic dermatitis.
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TLDR
An updated consensus recommendations for systemic treatment of AD in South Korea based on recent evidence and experience is provided and it is looked forward to implementing a new and updated consensus of systemic therapy in controlling patients with moderate-to-severe AD.
Selective IL-13 inhibitors for the treatment of atopic dermatitis
TLDR
Evidence supports the hypothesis that selective antagonism of IL-13 is sufficient to control AD, providing an improvement in the patient’s quality of life, and the development of lebrikizumab and tralokinumab represents a new and exciting phase in the management of AD.
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