Are A3 adenosine receptors expressed in the brain?

  title={Are A3 adenosine receptors expressed in the brain?},
  author={Scott A. Rivkees and Sundararajah Thevananther and H Hao},
  volume={11 5},
An increasing number of reports suggest a role for A3 adenosine receptors (A3ARs) in mediating adenosine action in the central nervous system. However, studies of A3AR localization in the brain have yet to be performed. To provide insights into the central sites of A3AR action, we compared patterns of A1 and A3AR mRNA and binding site expression in the brains of rats, mice and humans. We also assessed whether A3 agonists are selective for A3ARs. Whereas it was possible to detect high-level A1AR… CONTINUE READING

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