Are 20 human papillomavirus types causing cervical cancer?

@article{Arbyn2014Are2H,
  title={Are 20 human papillomavirus types causing cervical cancer?},
  author={Marc Arbyn and Massimo Tommasino and Christophe E. Depuydt and Joakim Dillner},
  journal={The Journal of Pathology},
  year={2014},
  volume={234}
}
In 2012, the International Agency for Research on Cancer concluded that there was consistent and sufficient epidemiological, experimental and mechanistic evidence of carcinogenicity to humans for 12 HPV types (HPV16, HPV18, HPV31, HPV33, HPV35, HPV39, HPV45, HPV51, HPV52, HPV56, HPV58 and HPV59) for cervical cancer. Therefore, these types were considered as 1A carcinogens. They all belong to the family of the α‐Papillomaviridae, in particular to the species α5 (HPV51), α6 (HPV56), α7 (HPV18… 
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References

SHOWING 1-10 OF 29 REFERENCES
Comparative Analysis of 19 Genital Human Papillomavirus Types with Regard to p53 Degradation, Immortalization, Phylogeny, and Epidemiologic Risk Classification
TLDR
Interestingly, the E6 proteins of HPV 53, 70, and 82 inconsistently risk classified in the literature were also found to induce p53 degradation, which could imply that other important functional differences exist between phylogenetically highly related viruses displaying similar biological properties in tissue culture that may affect their carcinogenicity in vivo.
The human papillomavirus family and its role in carcinogenesis.
Human papillomavirus is a necessary cause of invasive cervical cancer worldwide
TLDR
The presence of HPV in virtually all cervical cancers implies the highest worldwide attributable fraction so far reported for a specific cause of any major human cancer, and the rationale for HPV testing in addition to, or even instead of, cervical cytology in routine cervical screening.
Global Improvement in Genotyping of Human Papillomavirus DNA: the 2011 HPV LabNet International Proficiency Study
TLDR
A continuing global proficiency program has documented worldwide improvement in the comparability and reliability of HPV genotyping assay performances.
Biological activity of probable/possible high‐risk human papillomavirus types in cervical cancer
TLDR
The finding of viral oncogene transcription of pHR‐HPV types 26, 66, 70 and 82 in cervical tumors, in the absence of any other transcriptionally active HR‐type and with p16INK4a overexpression and pRb downregulation, may support a reassessment of the carcinogenicity classification of these p HR‐ HPV types.
Prevalence and viral load of 51 genital human papillomavirus types and three subtypes
Of the 120 known human papillomaviruses (HPV), 51 HPV types infect the genital mucosa. Very little is known about the prevalence and viral load of the majority of these low‐risk (Lr‐) HPV types in
Changes in type-specific human papillomavirus load predict progression to cervical cancer
TLDR
Serial type‐specific viral load measurements predict the natural history of HPV infections and could be used to triage women in HPV‐based cervical cancer screening.
Pathogenic role of the eight probably/possibly carcinogenic HPV types 26, 53, 66, 67, 68, 70, 73 and 82 in cervical cancer
TLDR
Molecular evidence of carcinogenicity for types currently classified as probably/possibly carcinogenic HR‐HPV types is provided, although this evidence is not sufficient for inclusion of these HPV types into population‐wide primary and secondary prevention programmes.
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