Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.

@article{Grossberg2010ArcuateNP,
  title={Arcuate nucleus proopiomelanocortin neurons mediate the acute anorectic actions of leukemia inhibitory factor via gp130.},
  author={Aaron J Grossberg and Jarrad M. Scarlett and Xinxia Zhu and Darren D Bowe and Ayesha K. Batra and Theodore P. Braun and Daniel L Marks},
  journal={Endocrinology},
  year={2010},
  volume={151 2},
  pages={606-16}
}
The proinflammatory cytokine leukemia inhibitory factor (LIF) is induced in disease states and is known to inhibit food intake when administered centrally. However, the neural pathways underlying this effect are not well understood. We demonstrate that LIF acutely inhibits food intake by directly activating pro-opiomelanocortin (POMC) neurons in the arcuate nucleus of the hypothalamus. We show that arcuate POMC neurons express the LIF-R, and that LIF stimulates the release of the anorexigenic… CONTINUE READING
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