Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons.

@article{Kurita2015ArcuateNS,
  title={Arcuate Na+,K+-ATPase senses systemic energy states and regulates feeding behavior through glucose-inhibited neurons.},
  author={Hideharu Kurita and Kai Y. Xu and Yuko Maejima and Masanori Nakata and Katsuya Dezaki and Putra Santoso and Yifei Yang and Takeshi Arai and Darambazar Gantulga and Shinji Muroya and Alan Kawarai Lefor and Masafumi Kakei and Eiju Watanabe and Toshihiko Yada},
  journal={American journal of physiology. Endocrinology and metabolism},
  year={2015},
  volume={309 4},
  pages={
          E320-33
        }
}
Feeding is regulated by perception in the hypothalamus, particularly the first-order arcuate nucleus (ARC) neurons, of the body's energy state. However, the cellular device for converting energy states to the activity of critical neurons in ARC is less defined. We here show that Na(+),K(+)-ATPase (NKA) in ARC senses energy states to regulate feeding. Fasting-induced systemic ghrelin rise and glucose lowering reduced ATP-hydrolyzing activity of NKA and its substrate ATP level, respectively… 
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