Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin★

  title={Arcuate AgRP neurons mediate orexigenic and glucoregulatory actions of ghrelin★},
  author={Qian Wang and Chen Liu and Aki Uchida and Jen-Chieh Chuang and Angela K. Walker and Tiemin Liu and Sherri Osborne-Lawrence and Brittany L. Mason and Christina A Mosher and Eric D. Berglund and Joel K Elmquist and Jeffrey M Zigman},
  booktitle={Molecular metabolism},
The hormone ghrelin stimulates eating and helps maintain blood glucose upon caloric restriction. While previous studies have demonstrated that hypothalamic arcuate AgRP neurons are targets of ghrelin, the overall relevance of ghrelin signaling within intact AgRP neurons is unclear. Here, we tested the functional significance of ghrelin action on AgRP neurons using a new, tamoxifen-inducible AgRP-CreER(T2) transgenic mouse model that allows spatiotemporally-controlled re-expression of… CONTINUE READING
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