Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both β-Amyloid Production and Clearance

@article{Zhu2013ArctigeninEA,
  title={Arctigenin Effectively Ameliorates Memory Impairment in Alzheimer's Disease Model Mice Targeting Both $\beta$-Amyloid Production and Clearance},
  author={Zhi-yuan Zhu and Jianming Yan and W. Jiang and Xin-gang Yao and J. Chen and Lili Chen and Chenjing Li and Li-hong Hu and H. Jiang and Xu Shen},
  journal={The Journal of Neuroscience},
  year={2013},
  volume={33},
  pages={13138 - 13149}
}
Alzheimer's disease (AD) chiefly characterizes a progressively neurodegenerative disorder of the brain, and eventually leads to irreversible loss of intellectual abilities. The β-amyloid (Aβ)-induced neurodegeneration is believed to be the main pathological mechanism of AD, and Aβ production inhibition or its clearance promotion is one of the promising therapeutic strategies for anti-AD research. Here, we report that the natural product arctigenin from Arctium lappa (L.) can both inhibit A… Expand
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References

SHOWING 1-10 OF 78 REFERENCES
ApoE-Directed Therapeutics Rapidly Clear β-Amyloid and Reverse Deficits in AD Mouse Models
Amyloid clearance as a treatment target against Alzheimer's disease.
Is BACE1 a suitable therapeutic target for the treatment of Alzheimer's disease? Current strategies and future directions
Amyloid beta-protein assembly as a therapeutic target of Alzheimer's disease.
BACE1 gene deletion prevents neuron loss and memory deficits in 5XFAD APP/PS1 transgenic mice
...
1
2
3
4
5
...