Architecture of the yeast origin recognition complex bound to origins of DNA replication.

@article{Lee1997ArchitectureOT,
  title={Architecture of the yeast origin recognition complex bound to origins of DNA replication.},
  author={Dongwhan Lee and Stephen P Bell},
  journal={Molecular and cellular biology},
  year={1997},
  volume={17 12},
  pages={7159-68}
}
In many organisms, the replication of DNA requires the binding of a protein called the initiator to DNA sites referred to as origins of replication. Analyses of multiple initiator proteins bound to their cognate origins have provided important insights into the mechanism by which DNA replication is initiated. To extend this level of analysis to the study of eukaryotic chromosomal replication, we have investigated the architecture of the Saccharomyces cerevisiae origin recognition complex (ORC… CONTINUE READING