Architecture of the yeast Elongator complex

  title={Architecture of the yeast Elongator complex},
  author={Maria I Dauden and Jan Kosinski and Olga Kolaj-Robin and Ambroise Desfosses and Alessandro Ori and C{\'e}line Faux and Niklas A. Hoffmann and Osita F. Onuma and Karin D Breunig and Martin Beck and Carsten Sachse and Bertrand S{\'e}raphin and Sebastian Glatt and Christoph W M{\"u}ller},
  booktitle={EMBO reports},
The highly conserved eukaryotic Elongator complex performs specific chemical modifications on wobble base uridines of tRNAs, which are essential for proteome stability and homeostasis. The complex is formed by six individual subunits (Elp1-6) that are all equally important for its tRNA modification activity. However, its overall architecture and the detailed reaction mechanism remain elusive. Here, we report the structures of the fully assembled yeast Elongator and the Elp123 sub-complex solved… CONTINUE READING
Recent Discussions
This paper has been referenced on Twitter 5 times over the past 90 days. VIEW TWEETS

From This Paper

Figures, tables, and topics from this paper.


Publications referenced by this paper.
Showing 1-10 of 73 references

Similar Papers

Loading similar papers…