Architecture of the nuclear pore complex coat

  title={Architecture of the nuclear pore complex coat},
  author={Tobias Stuwe and Ana Raquel Correia and Daniel H. Lin and Marcin Paduch and Vincent T. Lu and A. Kossiakoff and Andr{\'e} Hoelz},
The nuclear pore complex (NPC) constitutes the sole gateway for bidirectional nucleocytoplasmic transport. Despite half a century of structural characterization, the architecture of the NPC remains unknown. Here we present the crystal structure of a reconstituted ~400-kilodalton coat nucleoporin complex (CNC) from Saccharomyces cerevisiae at a 7.4 angstrom resolution. The crystal structure revealed a curved Y-shaped architecture and the molecular details of the coat nucleoporin interactions… CONTINUE READING