Architecture of the mammalian mechanosensitive Piezo1 channel

  title={Architecture of the mammalian mechanosensitive Piezo1 channel},
  author={Jingpeng Ge and Wanqiu Li and Qiancheng Zhao and Ningning Li and Maofei Chen and Peng Zhi and Ruochong Li and Ning Gao and Bailong Xiao and Maojun Yang},
Piezo proteins are evolutionarily conserved and functionally diverse mechanosensitive cation channels. However, the overall structural architecture and gating mechanisms of Piezo channels have remained unknown. Here we determine the cryo-electron microscopy structure of the full-length (2,547 amino acids) mouse Piezo1 (Piezo1) at a resolution of 4.8 Å. Piezo1 forms a trimeric propeller-like structure (about 900 kilodalton), with the extracellular domains resembling three distal blades and a… CONTINUE READING
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