Architecture of the major component of the type III secretion system export apparatus

  title={Architecture of the major component of the type III secretion system export apparatus},
  author={Patrizia Abrusci and Marta Vergara–Irigaray and Steven Johnson and Morgan D Beeby and David R. Hendrixson and Pietro Roversi and Miriam E. Friede and Janet E Deane and Grant J. Jensen and Christoph M Tang and Susan M Lea},
  booktitle={Nature Structural &Molecular Biology},
Type III secretion systems (T3SSs) are bacterial membrane–embedded nanomachines designed to export specifically targeted proteins from the bacterial cytoplasm. Secretion through T3SS is governed by a subset of inner membrane proteins termed the 'export apparatus'. We show that a key member of the Shigella flexneri export apparatus, MxiA, assembles into a ring essential for secretion in vivo. The ring-forming interfaces are well-conserved in both nonflagellar and flagellar homologs, implying… CONTINUE READING
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