Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers.

@article{Nossal2007ArchitectureOT,
  title={Architecture of the bacteriophage T4 replication complex revealed with nanoscale biopointers.},
  author={Nancy G. Nossal and Alexander M Makhov and Paul Chastain and Charles Ellwood Jones and Jack D. Griffith},
  journal={The Journal of biological chemistry},
  year={2007},
  volume={282 2},
  pages={
          1098-108
        }
}
Our previous electron microscopy of DNA replicated by the bacteriophage T4 proteins showed a single complex at the fork, thought to contain the leading and lagging strand proteins, as well as the protein-covered single-stranded DNA on the lagging strand folded into a compact structure. "Trombone" loops formed from nascent lagging strand fragments were present on a majority of the replicating molecules (Chastain, P., Makhov, A. M., Nossal, N. G., and Griffith, J. D. (2003) J. Biol. Chem. 278… CONTINUE READING

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