Architecture of the Saccharomyces cerevisiae SAGA transcription coactivator complex.

Abstract

The conserved transcription coactivator SAGA is comprised of several modules that are involved in activator binding, TBP binding, histone acetylation (HAT) and deubiquitination (DUB). Crosslinking and mass spectrometry, together with genetic and biochemical analyses, were used to determine the molecular architecture of the SAGA-TBP complex. We find that the… (More)
DOI: 10.15252/embj.201488638

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