Architecture of the Saccharomyces cerevisiae Origin Recognition Complex Bound to Origins of DNA Replication

Abstract

The Origin Recognition Complex (ORC) is thought to be required for the initiation of DNA replication in all eukaryotes. In Saccharomyces cerevisiae, ORC is bound to origins of DNA replication throughout the cell cycle and directs the assembly of higher-order protein-DNA complexes during G1. I have investigated the architecture of yeast ORC bound to origin… (More)

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