Architecture of the SARS coronavirus prefusion spike

  title={Architecture of the SARS coronavirus prefusion spike},
  author={Daniel R. Beniac and Anton Andonov and Elsie Grudeski and Tim F. Booth},
  journal={Nature Structural &Molecular Biology},
The emergence in 2003 of a new coronavirus (CoV) responsible for the atypical pneumonia termed severe acute respiratory syndrome (SARS) was a stark reminder that hitherto unknown viruses have the potential to cross species barriers to become new human pathogens. Here we describe the SARS-CoV 'spike' structure determined by single-particle cryo-EM, along with the docked atomic structures of the receptor-binding domain and prefusion core. 

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