Architecture of human mTOR complex 1

@article{Aylett2016ArchitectureOH,
  title={Architecture of human mTOR complex 1},
  author={Christopher Hs Aylett and Evelyn Sauer and Stefan Imseng and Daniel Boehringer and Michael N. Hall and Nenad Ban and Timm Maier},
  journal={Science},
  year={2016},
  volume={351},
  pages={48-52}
}
Target of rapamycin (TOR), a conserved protein kinase and central controller of cell growth, functions in two structurally and functionally distinct complexes: TORC1 and TORC2. Dysregulation of mammalian TOR (mTOR) signaling is implicated in pathologies that include diabetes, cancer, and neurodegeneration. We resolved the architecture of human mTORC1 (mTOR with subunits Raptor and mLST8) bound to FK506 binding protein (FKBP)–rapamycin, by combining cryo–electron microscopy at 5.9 angstrom… CONTINUE READING
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