Architecture of Ure2p prion filaments: the N-terminal domains form a central core fiber.

@article{Baxa2003ArchitectureOU,
  title={Architecture of Ure2p prion filaments: the N-terminal domains form a central core fiber.},
  author={Ulrich Baxa and Kimberly L. Taylor and Joseph S. Wall and Martha N. Simon and Naiqian Cheng and Reed B Wickner and Alasdair C. Steven},
  journal={The Journal of biological chemistry},
  year={2003},
  volume={278 44},
  pages={43717-27}
}
The [URE3] prion is an inactive, self-propagating, filamentous form of the Ure2 protein, a regulator of nitrogen catabolism in yeast. The N-terminal "prion" domain of Ure2p determines its in vivo prion properties and in vitro amyloid-forming ability. Here we determined the overall structures of Ure2p filaments and related polymers of the prion domain fused to other globular proteins. Protease digestion of 25-nm diameter Ure2p filaments trimmed them to 4-nm filaments, which mass spectrometry… CONTINUE READING

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