Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation

@article{Yankovskaya2003ArchitectureOS,
  title={Architecture of Succinate Dehydrogenase and Reactive Oxygen Species Generation},
  author={Victoria Yankovskaya and Rob Horsefield and Susanna T{\"o}rnroth and Cesar Luna-Chavez and Hideto Miyoshi and Christophe L{\'e}ger and Bernadette Byrne and Gary Cecchini and So Iwata},
  journal={Science},
  year={2003},
  volume={299},
  pages={700 - 704}
}
The structure of Escherichia colisuccinate dehydrogenase (SQR), analogous to the mitochondrial respiratory complex II, has been determined, revealing the electron transport pathway from the electron donor, succinate, to the terminal electron acceptor, ubiquinone. It was found that the SQR redox centers are arranged in a manner that aids the prevention of reactive oxygen species (ROS) formation at the flavin adenine dinucleotide. This is likely to be the main reason SQR is expressed during… Expand
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TLDR
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Supramolecular organizations in the aerobic respiratory chain of Escherichia coli.
TLDR
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The Superfamily of Succinate:Quinone Oxidoreductases and its Implications for the Cyanobacterial Enzymes
Membrane-bound succinate dehydrogenases (succinate:quinone reductases, SQR) and fumarate reductases (quinol:fumarate reductases, QFR) couple the oxidation of succinate to fumarate to the reduction ofExpand
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