Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.

@article{Costanzi2004ArchitectureOP,
  title={Architecture of P2Y nucleotide receptors: structural comparison based on sequence analysis, mutagenesis, and homology modeling.},
  author={S. Costanzi and L. Mamedova and Zhang-Guo Gao and K. Jacobson},
  journal={Journal of medicinal chemistry},
  year={2004},
  volume={47 22},
  pages={
          5393-404
        }
}
Human P2Y receptors encompass at least eight subtypes of Class A G protein-coupled receptors (GPCRs), responding to adenine and/or uracil nucleotides. Using a BLAST search against the Homo sapiens subset of the SWISS-PROT and TrEMBL databases, we identified 68 proteins showing high similarity to P2Y receptors. To address the problem of low sequence identity between rhodopsin and the P2Y receptors, we performed a multiple-sequence alignment of the retrieved proteins and the template bovine… Expand
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  • S. Costanzi
  • Biology, Medicine
  • Methods in molecular biology
  • 2012
Molecular Structure of P2Y Receptors: Mutagenesis, Modeling, and Chemical Probes.
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