Architecture of Chimeric Spheroids Controls Drug Transport

@article{Curran2015ArchitectureOC,
  title={Architecture of Chimeric Spheroids Controls Drug Transport},
  author={Sean Curran and Marguerite M Vantangoli and Kim Boekelheide and Jeffrey R. Morgan},
  journal={Cancer Microenvironment},
  year={2015},
  volume={8},
  pages={101-109}
}
It is well-established that upregulation of drug efflux pumps leads to multi-drug resistance. Less is known about the role of the architecture of the tumor microenvironment in this process: how the location of pump expressing cells influences drug exposure to cancerous as well as non-cancerous cells. Here, we report a 3D in vitro model of spheroids with mixtures of cells expressing high and low levels of ABCG2, quantifying pump activity by the ability to reject the fluorescent dye Hoechst 33342… CONTINUE READING

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