Architecture and functional dynamics of the pentafunctional AROM complex

@article{AroraVeraszt2020ArchitectureAF,
  title={Architecture and functional dynamics of the pentafunctional AROM complex},
  author={Harshul Arora Veraszt{\'o} and Maria Logotheti and Reinhard Albrecht and Alexander Leitner and Hongbo Zhu and Marcus D. Hartmann},
  journal={Nature Chemical Biology},
  year={2020},
  pages={1-6}
}
The AROM complex is a multifunctional metabolic machine with ten enzymatic domains catalyzing the five central steps of the shikimate pathway in fungi and protists. We determined its crystal structure and catalytic behavior, and elucidated its conformational space using a combination of experimental and computational approaches. We derived this space in an elementary approach, exploiting an abundance of conformational information from its monofunctional homologs in the Protein Data Bank. It… 
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Molecular analysis and essentiality of Aro1 shikimate biosynthesis multi-enzyme in Candida albicans
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Channeling a complex question.
It is generally believed that large protein complexes provide a catalytic advantage due to substrate channeling between enzymatic domains. However, the structure and function of the pentafunctional
Channeling a complex question
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The structure and function of the pentafunctional AROM complex suggests a noteworthy exception to the belief that large protein complexes provide a catalytic advantage due to substrate channeling between enzymatic domains.

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