Architecture and functional dynamics of the pentafunctional AROM complex

  title={Architecture and functional dynamics of the pentafunctional AROM complex},
  author={Harshul Arora Veraszt{\'o} and Maria Logotheti and Reinhard Albrecht and Alexander Leitner and Hongbo Zhu and Marcus D. Hartmann},
  journal={Nature Chemical Biology},
The AROM complex is a multifunctional metabolic machine with ten enzymatic domains catalyzing the five central steps of the shikimate pathway in fungi and protists. We determined its crystal structure and catalytic behavior, and elucidated its conformational space using a combination of experimental and computational approaches. We derived this space in an elementary approach, exploiting an abundance of conformational information from its monofunctional homologs in the Protein Data Bank. It… 
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