Architecture and Secondary Structure of an Entire HIV-1 RNA Genome

  title={Architecture and Secondary Structure of an Entire HIV-1 RNA Genome},
  author={Joseph M. Watts and Kristen K. Dang and Robert J. Gorelick and Christopher W. Leonard and Julian W. Bess and Ronald Swanstrom and Christina L Burch and Kevin M Weeks},
Single-stranded RNA viruses encompass broad classes of infectious agents and cause the common cold, cancer, AIDS and other serious health threats. Viral replication is regulated at many levels, including the use of conserved genomic RNA structures. Most potential regulatory elements in viral RNA genomes are uncharacterized. Here we report the structure of an entire HIV-1 genome at single nucleotide resolution using SHAPE, a high-throughput RNA analysis technology. The genome encodes protein… CONTINUE READING
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