Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits

  title={Architecture-Dependent Noise Discriminates Functionally Analogous Differentiation Circuits},
  author={Tolga Cagatay and Marc Turcotte and Michael B. Elowitz and Jordi Garc{\'i}a-Ojalvo and G{\"u}rol M. S{\"u}el},
Gene regulatory circuits with different architectures (patterns of regulatory interactions) can generate similar dynamics. This raises the question of why a particular circuit architecture is selected to implement a given cellular process. To investigate this problem, we compared the Bacillus subtilis circuit that regulates differentiation into the competence state to an engineered circuit with an alternative architecture (SynEx) in silico and in vivo. Time-lapse microscopy measurements showed… CONTINUE READING
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