Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription.

@article{Yu2000ArchitecturalTF,
  title={Architectural transcription factors and the SAGA complex function in parallel pathways to activate transcription.},
  author={Yaxin Yu and Peter J. Eriksson and David J Stillman},
  journal={Molecular and cellular biology},
  year={2000},
  volume={20 7},
  pages={2350-7}
}
Recent work has shown that transcription of the yeast HO gene involves the sequential recruitment of a series of transcription factors. We have performed a functional analysis of HO regulation by determining the ability of mutations in SIN1, SIN3, RPD3, and SIN4 negative regulators to permit HO expression in the absence of certain activators. Mutations in the SIN1 (=SPT2) gene do not affect HO regulation, in contrast to results of other studies using an HO:lacZ reporter, and our data show that… CONTINUE READING