Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD.

@article{Fidziaska2003ArchitecturalAI,
  title={Architectural abnormalities in muscle nuclei. Ultrastructural differences between X-linked and autosomal dominant forms of EDMD.},
  author={Anna Fidziańska and Irena Hausmanowa-Petrusewicz},
  journal={Journal of the neurological sciences},
  year={2003},
  volume={210 1-2},
  pages={47-51}
}
OBJECTIVES The aim of our study was to compare the ultrastructure of myonuclei in both forms of Emery-Dreifuss dystrophy (EDMD)-X-linked and dominantly autosomally transmitted. The muscle biopsies were taken from rectus femoris in four X-linked EDMD cases and three ADEDMD cases. METHODS The biopsies were evaluated using immunocytochemical staining to establish emerin or A/C lamins deficiency. The muscle ultrastructure, especially that of nuclei, was analysed to find out whether there are… CONTINUE READING