Architectural Correlates of Myocardial Conduction: Changes to the Topography of Cellular Coupling, Intracellular Conductance, and Action Potential Propagation with Hypertrophy in Guinea-Pig Ventricular Myocardium

  title={Architectural Correlates of Myocardial Conduction: Changes to the Topography of Cellular Coupling, Intracellular Conductance, and Action Potential Propagation with Hypertrophy in Guinea-Pig Ventricular Myocardium},
  author={Christopher Henry Fry and Rosaire Gray and Paramdeep S. Dhillon and Rita I. Jabr and Emmanuel Dupont and Pravina M. Patel and Nicholas S. Peters},
  journal={Circulation: Arrhythmia and Electrophysiology},
  • C. FryR. Gray N. Peters
  • Published 1 December 2014
  • Biology, Medicine
  • Circulation: Arrhythmia and Electrophysiology
Background—We tested the hypothesis that alterations to action potential conduction velocity (CV) and conduction anisotropy in left ventricular hypertrophy are associated with topographical changes to gap-junction coupling and intracellular conductance by measuring these variables in the same preparations. Methods and Results—Left ventricular papillary muscles were excised from aortic-banded or sham-operated guinea-pig hearts. With intracellular stimulating and recording microelectrodes, CV was… 

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