Archetypal organization of the amphioxus Hox gene cluster

@article{GarciaFernndez1994ArchetypalOO,
  title={Archetypal organization of the amphioxus Hox gene cluster},
  author={Jordi Garcia-Fern{\'a}ndez and Peter W. H. Holland},
  journal={Nature},
  year={1994},
  volume={370},
  pages={563-566}
}
ORGANIZATION into gene clusters is an essential and diagnostic feature of Hox genes1. Insect and nematode genomes possess single Hox gene clusters (split in Drosophila); in mammals, there are 38 Hox genes in four clusters on different chromosomes2,3. A collinear relationship between chromosomal position, activation time and anterior expression limit of vertebrate Hox genes suggests that clustering may be important for precise spatiotemporal gene regulation and hence embryonic patterning2,4. Hox… Expand
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TLDR
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TLDR
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Hox cluster genes and collinearities throughout the tree of animal life.
  • S. Gaunt
  • Biology, Medicine
  • The International journal of developmental biology
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TLDR
The conclusion is that the protostome-deuterostome ancestor of 99% of all described animal species, must already have had this same basic Hox cluster, and that it probably used it in the same way to establish its body plan. Expand
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