Archazolid and apicularen: Novel specific V-ATPase inhibitors

  title={Archazolid and apicularen: Novel specific V-ATPase inhibitors},
  author={Markus Huss and Florenz Sasse and Brigitte Kunze and Heinrich Steinmetz and Gudrun Ingenhorst and Axel Zeeck and Helmut Wieczorek},
  journal={BMC Biochemistry},
  pages={13 - 13}
V-ATPases constitute a ubiquitous family of heteromultimeric, proton translocating proteins. According to their localization in a multitude of eukaryotic membranes, they energize many different transport processes. Since their malfunction is correlated with various diseases in humans, the elucidation of the properties of this enzyme for the development of selective inhibitors and drugs is one of the challenges in V-ATPase research. Archazolid A and B, two recently discovered cytotoxic… CONTINUE READING
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