Archaeal tetraether lipids

@article{Hanford2002ArchaealTL,
  title={Archaeal tetraether lipids},
  author={M. Hanford and T. Peeples},
  journal={Applied Biochemistry and Biotechnology},
  year={2002},
  volume={97},
  pages={45-62}
}
The extremely stable biomolecules manufactured by organisms from extreme environments are of great scientific and engineering interest in the development of robust and stable industrial biocatalysts. Identification of molecules that impart stability under extremes will also have a profound impact on our understanding of cellular survival. This review discusses isolation and characterization of archaeal tetraethers as well as target technologies for tetraether lipid application. The isolation… Expand

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References

SHOWING 1-10 OF 68 REFERENCES
Archaeal lipids and their biotechnological applications
TLDR
The molecular organization of archaeal lipids in monolayers, artificial black membranes and vesicles and the unique properties and possible biotechnological applications of liposomes of the lipids are presented. Expand
The essence of being extremophilic: the role of the unique archaeal membrane lipids
TLDR
It is shown that thermophilic and extreme acidophilic Archaea possess membrane-spanning tetraether lipids that form a rigid monolayer membrane which is nearly impermeable to ions and protons, making the archaeal lipid membranes more suitable for life and survival in extreme environments than the ester-type bilayer lipids of Bacteria or Eukarya. Expand
Stability of pressure-extruded liposomes made from archaeobacterial ether lipids
TLDR
Leakage rates of entrapped fluorescent or radioactive compounds established that those archaeobacterial liposomes that contained tetraether lipids were the most stable to high temperatures, alkaline pH, and serum proteins. Expand
Extremely Thermophilic Microorganisms
The community of extremely thermophilic microorganisms that prospers in geothermal environments uses a variety of metabolic strategies for carbon assimilation and energy conservation (see TABLE 1).Expand
Archaeobacterial ether lipid liposomes (archaeosomes) as novel vaccine and drug delivery systems.
Liposomes are artificial, spherical, closed vesicles consisting of one or more lipid bilayer(s). Liposomes made from ester phospholipids have been studied extensively over the last 3 decades asExpand
In vitro assessment of archaeosome stability for developing oral delivery systems.
TLDR
The results indicate that archaeosomes show stability properties indicative of potential advantages in developing applications as an oral delivery system under conditions encountered in the human gastrointestinal tract. Expand
Structure and polymorphism of bipolar isopranyl ether lipids from archaebacteria.
TLDR
The structure and polymorphism of a variety of lipids extracted from Sulfolobus solfataricus, an extreme thermoacidophilic archaebacterium growing at about 85 degrees C and pH 2.5 is described. Expand
Tetraether lipid components from a thermoacidophilic archaebacterium. Chemical structure and physical polymorphism.
TLDR
Results corroborate the previous conjectures regarding the correlations between the structure of the plasma membrane, the phase behaviour of the lipid extract and life at high temperature and confirm the previous conclusion that, in the presence of a sufficient amount of water, the unsubstituted glycerol headgroups partition preferentially in the hydrocarbon regions rather than at the polar/apolar interfaces. Expand
Isoprenoid ethers; backbone of complex lipids of the archaebacterium Sulfolobus solfataricus
TLDR
Individual isoprenoid ethers, backbone of complex lipids, are separated by high-performance liquid chromatography (HPLC) and the structures of 20 different species are fully described, which allow previous observations on these and related lipids to be rationalized biosynthetically. Expand
Energy transduction and transport processes in thermophilic bacteria
TLDR
Genetic and biochemical studies of bacterial growth at the extremes of temperature reveal fundamental principles of adaptations to life at extreme temperatures and the recent development of reconstitution techniques using membrane-spanning lipids allows a rigorous biochemical characterization of membrane proteins of extreme thermophiles in their natural environment. Expand
...
1
2
3
4
5
...