Archaeal phylogeny: reexamination of the phylogenetic position of Archaeoglobus fulgidus in light of certain composition-induced artifacts.

@article{Woese1991ArchaealPR,
  title={Archaeal phylogeny: reexamination of the phylogenetic position of Archaeoglobus fulgidus in light of certain composition-induced artifacts.},
  author={Carl R. Woese and Laurie A. Achenbach and Philippe Rouvi{\`e}re and Linda Mandelco},
  journal={Systematic and applied microbiology},
  year={1991},
  volume={14 4},
  pages={364-71}
}
A major and too little recognized source of artifact in phylogenetic analysis of molecular sequence data is compositional difference among sequences. The problem becomes particularly acute when alignments contain ribosomal RNAs from both mesophilic and thermophilic species. Among prokaryotes the latter are considerably higher in G + C content than the former, which often results in artificial clustering of thermophilic lineages and their being placed artificially deep in phylogenetic trees. In… CONTINUE READING