Archaeal MCM has separable processivity, substrate choice and helicase domains

@inproceedings{Barry2007ArchaealMH,
  title={Archaeal MCM has separable processivity, substrate choice and helicase domains},
  author={Elizabeth R. Barry and Adam T. McGeoch and Zvi Kelman and Stephen D Bell},
  booktitle={Nucleic acids research},
  year={2007}
}
The mini-chromosome maintenance (MCM) complex is the principal candidate for the replicative helicase of archaea and eukaryotes. Here, we describe a functional dissection of the roles of the three principal structural modules of the homomultimeric MCM of the hyperthermophilic archaeon Sulfolobus solfataricus. Our results include the first analysis of the central AAA+ domain in isolation. This domain possesses ATPase and helicase activity, defining this as the minimal helicase domain… CONTINUE READING

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