Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation.

@article{Englert2011Archaeal3R,
  title={Archaeal 3'-phosphate RNA splicing ligase characterization identifies the missing component in tRNA maturation.},
  author={Markus Englert and Kelly Ann Sheppard and Aaron Aslanian and John R. Yates and Dieter S{\"o}ll},
  journal={Proceedings of the National Academy of Sciences of the United States of America},
  year={2011},
  volume={108 4},
  pages={1290-5}
}
Intron removal from tRNA precursors involves cleavage by a tRNA splicing endonuclease to yield tRNA 3'-halves beginning with a 5'-hydroxyl, and 5'-halves ending in a 2',3'-cyclic phosphate. A tRNA ligase then incorporates this phosphate into the internucleotide bond that joins the two halves. Although this 3'-P RNA splicing ligase activity was detected almost three decades ago in extracts from animal and later archaeal cells, the protein responsible was not yet identified. Here we report the… CONTINUE READING

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