Arc in synaptic plasticity: from gene to behavior

  title={Arc in synaptic plasticity: from gene to behavior},
  author={Erica Korb and Steven Finkbeiner},
  journal={Trends in Neurosciences},
The activity-regulated cytoskeletal (Arc) gene encodes a protein that is critical for memory consolidation. Arc is one of the most tightly regulated molecules known: neuronal activity controls Arc mRNA induction, trafficking and accumulation, and Arc protein production, localization and stability. Arc regulates synaptic strength through multiple mechanisms and is involved in essentially every known form of synaptic plasticity. It also mediates memory formation and is implicated in multiple… CONTINUE READING
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